Pharmacotherapies for smoking cessation: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Many placebo-controlled trials have demonstrated the efficacy of individual pharmacotherapies approved for smoking cessation. However, few direct or indirect comparisons of such interventions have been conducted. We performed a meta-analysis to compare the treatment effects of 7 approved pharmacologic interventions for smoking cessation.

Methods

We searched the US Centers for Disease Control and Prevention's Tobacco Information and Prevention database as well as MEDLINE, EMBASE and the Cochrane Library for published reports of placebo-controlled, double-blind randomized controlled trials of pharmacotherapies for smoking cessation. We included studies that reported biochemically validated measures of abstinence at 6 and 12 months. We used a hierarchical Bayesian ra

SUBMITTER: Eisenberg MJ 

PROVIDER: S-EPMC2443223 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature