Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium.

ABSTRACT:

Background

Phagocytosis plays a major role in the defense of higher organisms against microbial infection and provides also the basis for antigen processing in the immune response. Cells of the model organism Dictyostelium are professional phagocytes that exploit phagocytosis of bacteria as the preferred way to ingest food, besides killing pathogens. We have investigated Dictyostelium differential gene expression during phagocytosis of non-pathogenic bacteria, using DNA microarrays, in order to identify molecular functions and novel genes involved in phagocytosis.

Results

The gene expression profiles of cells incubated for a brief time with bacteria were compared with cells either incubated in axenic medium or growing on bacteria. Transcriptional changes during exponential g

SUBMITTER: Sillo A 

PROVIDER: S-EPMC2443395 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature