Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.

ABSTRACT:

Context

Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression.

Objective

To examine whether the effects of child abuse on adult depressive symptoms are moderated by genetic polymorphisms within the corticotropin-releasing hormone type 1 receptor (CRHR1) gene.

Design

Association study examining gene x environment interactions between genetic polymorphisms at the CRHR1 locus and measures of child abuse on adult depressive symptoms.

Setting

General medical clinics of a large, public, urba

SUBMITTER: Bradley RG 

PROVIDER: S-EPMC2443704 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature