A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases.

ABSTRACT: For assessment of genetic association between single-nucleotide polymorphisms (SNPs) and disease status, the logistic-regression model or generalized linear model is typically employed. However, testing for deviation from Hardy-Weinberg proportion in a patient group could be another approach for genetic-association studies. The Hardy-Weinberg proportion is one of the most important principles in population genetics. Deviation from Hardy-Weinberg proportion among cases (patients) could provide additional evidence for the association between SNPs and diseases. To develop a more powerful statistical test for genetic-association studies, we combined evidence about deviation from Hardy-Weinberg proportion in case subjects and standard regression approaches that use case and control subjects. In

SUBMITTER: Wang J 

PROVIDER: S-EPMC2443842 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature