Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

ABSTRACT: Antifungal susceptibility testing of molds has been standardized in Europe and in the United States. Aspergillus fumigatus strains with resistance to azole drugs have recently been detected and the underlying molecular mechanisms of resistance characterized. Three hundred and ninety-three isolates, including 32 itraconazole-resistant strains, were used to define wild-type populations, epidemiological cutoffs, and cross-resistance between azole drugs. The epidemiological cutoff for itraconazole, voriconazole, and ravuconazole for the wild-type populations of A. fumigatus was < or =1 mg/liter. For posaconazole, the epidemiological cutoff was < or =0.25 mg/liter. Up till now, isolates susceptible to itraconazole have not yet displayed resistance to other azole drugs. Cross-resistance between

SUBMITTER: Rodriguez-Tudela JL 

PROVIDER: S-EPMC2443929 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature