A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness.

ABSTRACT:

Background

While much progress has been made in understanding stem cell (SC) function, a complete description of the molecular mechanisms regulating SCs is not yet established. This lack of knowledge is a major barrier holding back the discovery of therapeutic uses of SCs. We investigated the value of a novel meta-analysis of microarray gene expression in mouse SCs to aid the elucidation of regulatory mechanisms common to SCs and particular SC types.

Methodology/principal findings

We added value to previously published microarray gene expression data by characterizing the promoter type likely to regulate transcription. Promoters of up-regulated genes in SCs were characterized in terms of alternative promoter (AP) usage and CpG-richness, with the aim of correlating features k

SUBMITTER: Edwards YJ 

PROVIDER: S-EPMC2444034 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature