A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers.

ABSTRACT: Successful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing these opposing activities are likely to require tight regulation, because even subtle alterations in their expression may disrupt this balance with major consequences for various cancer-associated phenotypes. Here, we describe a cassette of cancer-specific genes exhibiting precise transcriptional control in solid tumors. Mining a database of tumor gene expression profiles from six different tissues, we identified 48 genes exhibiting highly restricted levels of gene expression variation in tumors (n = 270) compared to nonmalignant tissues (n = 71). Comprising genes linked to multiple cancer-related pathways, the restricted expression of

SUBMITTER: Yu K 

PROVIDER: S-EPMC2444049 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature