Identification of a novel trimeric autotransporter adhesin in the cryptic genospecies of Haemophilus.

ABSTRACT: Haemophilus biotype IV strains belonging to the recently recognized Haemophilus cryptic genospecies are an important cause of maternal genital tract and neonatal systemic infections and initiate infection by colonizing the genital or respiratory epithelium. To gain insight into the mechanism of Haemophilus cryptic genospecies colonization, we began by examining prototype strain 1595 and three other strains for adherence to genital and respiratory epithelial cell lines. Strain 1595 and two of the three other strains demonstrated efficient adherence to all of the cell lines tested. With a stably adherent variant of strain 1595, we generated a Mariner transposon library and identified 16 nonadherent mutants. All of these mutants lacked surface fibers and contained an insertion in the same ope

SUBMITTER: Sheets AJ 

PROVIDER: S-EPMC2446753 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature