Spontaneous amplification of the actinorhodin gene cluster in Streptomyces coelicolor involving native insertion sequence IS466.

ABSTRACT: We observed a spontaneous amplification of the Streptomyces coelicolor chromosome, including genes encoding biosynthetic enzymes of the antibiotic actinorhodin. A new junction of two tandem segments has, inserted within it, a third copy of a transposable element existing in two places elsewhere in the chromosome, suggesting its involvement in the amplification mechanism.

SUBMITTER: Widenbrant EM 

PROVIDER: S-EPMC2446789 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature