The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system.

ABSTRACT: Francisella tularensis is a highly infectious, facultative intracellular bacterial pathogen that is the causative agent of tularemia. Nearly a century ago, researchers observed that tularemia was often fatal in North America but almost never fatal in Europe and Asia. The chromosomes of F. tularensis strains carry two identical copies of the Francisella pathogenicity island (FPI), and the FPIs of North America-specific biotypes contain two genes, anmK and pdpD, that are not found in biotypes that are distributed over the entire Northern Hemisphere. In this work, we studied the contribution of anmK and pdpD to virulence by using F. novicida, which is very closely related to F. tularensis but which carries only one copy of the FPI. We showed that anmK and pdpD are necessary for full virulence

SUBMITTER: Ludu JS 

PROVIDER: S-EPMC2446798 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature