In vitro replication of varicella-zoster virus in human retinal pigment epithelial cells.

ABSTRACT: Here we describe for the first time the productive in vitro infection of human retinal pigment epithelial cells by varicella-zoster virus (VZV), resulting in a typical cytopathic effect (CPE) that is characterized by enlarged cells with increased granularity. Depending on the CPE dissemination, high titers of up to 1.6 x 10(6) PFU of cell-free and cryostable VZV/ml can be recovered.

SUBMITTER: Schmidt-Chanasit J 

PROVIDER: S-EPMC2446866 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature