Prevalence and sequence diversity of a factor required for actin-based motility in natural populations of Burkholderia species.

ABSTRACT: Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions.

SUBMITTER: Sitthidet C 

PROVIDER: S-EPMC2446894 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature