Type II secretory pathway for surface secretion of DraD invasin from the uropathogenic Escherichia coli Dr+ strain.

ABSTRACT: The virulence of the uropathogenic Escherichia coli Dr(+) IH11128 strain is associated with the presence of Dr fimbrial structures and a DraD invasin which can act as a fimbrial capping domain at the bacterial cell surface. However, a recent study suggests that the DraD protein is surface exposed in two forms: fimbria associated and fimbria nonassociated (prone to interaction with the N-terminal extension of the DraE protein located on the fimbrial tip). The actual mechanism of DraD surface secretion is presently unknown. We identified a previously unrecognized type II secretory pathway (secreton) in the uropathogenic E. coli Dr(+) strain which is well conserved among gram-negative bacteria and used mainly for secretion of virulence determinants. An active secreton is composed of 12 to 15

SUBMITTER: Zalewska-Piatek B 

PROVIDER: S-EPMC2447028 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature