Ontology highlight
ABSTRACT:
SUBMITTER: Shen WF
PROVIDER: S-EPMC2447122 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Shen Wei-Fang WF Hu Yu-Long YL Uttarwar Lalita L Passegue Emmanuelle E Largman Corey C
Molecular and cellular biology 20080512 14
The PicTar program predicted that microRNA-126 (miR-126), miR-145, and let-7s target highly conserved sites within the Hoxa9 homeobox. There are increased nucleotide constraints in the three microRNA seed sites among Hoxa9 genes beyond that required to maintain protein identity, suggesting additional functional conservation. In preliminary experiments, forced expression of these microRNAs in Hoxa9-immortalized bone marrow cells downregulated the HOXA9 protein and caused loss of biological activi ...[more]