Circulating plasma factors induce tubular and glomerular alterations in septic burns patients.

ABSTRACT:

Background

Severe burn is a systemic illness often complicated by sepsis. Kidney is one of the organs invariably affected, and proteinuria is a constant clinical finding. We studied the relationships between proteinuria and patient outcome, severity of renal dysfunction and systemic inflammatory state in burns patients who developed sepsis-associated acute renal failure (ARF). We then tested the hypothesis that plasma in these patients induces apoptosis and functional alterations that could account for proteinuria and severity of renal dysfunction in tubular cells and podocytes.

Methods

We studied the correlation between proteinuria and indexes of systemic inflammation or renal function prospectively in 19 severe burns patients with septic shock and ARF, and we evaluated the

SUBMITTER: Mariano F 

PROVIDER: S-EPMC2447585 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature