PFlexAna: detecting conformational changes in remotely related proteins.

ABSTRACT: The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/.

SUBMITTER: Nigham A 

PROVIDER: S-EPMC2447781 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature