Pathway analysis reveals functional convergence of gene expression profiles in breast cancer.

ABSTRACT:

Background

A recent study has shown high concordance of several breast-cancer gene signatures in predicting disease recurrence despite minimal overlap of the gene lists. It raises the question if there are common themes underlying such prediction concordance that are not apparent on the individual gene-level. We therefore studied the similarity of these gene-signatures on the basis of their functional annotations.

Results

We found the signatures did not identify the same set of genes but converged on the activation of a similar set of oncogenic and clinically-relevant pathways. A clear and consistent pattern across the four breast cancer signatures is the activation of the estrogen-signaling pathway. Other common features include BRCA1-regulated pathway, reck pathways, and i

SUBMITTER: Shen R 

PROVIDER: S-EPMC2447843 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature