Psoriasis is associated with increased beta-defensin genomic copy number.

ABSTRACT: Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

SUBMITTER: Hollox EJ 

PROVIDER: S-EPMC2447885 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature