Inadequate protein intake affects skeletal muscle transcript profiles in older humans.

ABSTRACT:

Background

Inadequate dietary protein intake causes adverse changes in the morphology and function of skeletal muscle. These changes may be reflected in early alterations in muscle messenger RNA levels.

Objective

This study assessed whether inadequate protein intake differentially affects skeletal muscle transcript concentrations and expression profiles in older adults.

Design

Twenty-one older men and women (aged 55-80 y) consumed controlled diets that provided 1.2 g protein x kg(-1) x d(-1) (adequate protein) for 1 wk and then were randomly assigned to consume either 0.5 g protein x kg(-1) x d(-1) [inadequate protein (IP) group; n=11] or 1.2 g protein x kg(-1) x d(-1) (control group; n=10) for a second week. RNA was isolated from fasting-state vastus lateralis biopsy

SUBMITTER: Thalacker-Mercer AE 

PROVIDER: S-EPMC2447912 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature