Imaging mass spectrometry reveals unique protein profiles during embryo implantation.

ABSTRACT: A reciprocal interaction between the implantation-competent blastocyst and receptive uterus is an absolute requirement for implantation, a process crucial for pregnancy success. A comprehensive understanding of this interaction has yet to be realized. One major difficulty in clearly defining this discourse is the complexity of the implantation process involving heterogeneous cell types of both the uterus and blastocyst, each endowed with unique molecular signatures that show dynamic changes during the course of pregnancy. Whereas gene expression studies by in situ hybridization or immunohistochemistry have shown differential expression patterns of specific genes during implantation, there is no report how numerous signaling proteins are spatially displayed at specific times and stages of i

SUBMITTER: Burnum KE 

PROVIDER: S-EPMC2453082 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature