The METEX study: methotrexate versus expectant management in women with ectopic pregnancy: a randomised controlled trial.

ABSTRACT:

Background

Patients with ectopic pregnancy (EP) and low serum hCG concentrations and women with a pregnancy of unknown location (PUL) and plateauing serum hCG levels are commonly treated with systemic methotrexate (MTX). However, there is no evidence that treatment in these particular subgroups of women is necessary as many of these early EPs may resolve spontaneously. The aim of this study is whether expectant management in women with EP or PUL and with low but plateauing serum hCG concentrations is an alternative to MTX treatment in terms of treatment success, future pregnancy, health related quality of life and costs.

Methods/design

A multicentre randomised controlled trial in The Netherlands. Hemodynamically stable patients with an EP visible on transvaginal ultrasound a

SUBMITTER: van Mello NM 

PROVIDER: S-EPMC2453103 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature