Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions.

ABSTRACT:

Background

One of the many gene families that expanded in early vertebrate evolution is the neuropeptide (NPY) receptor family of G-protein coupled receptors. Earlier work by our lab suggested that several of the NPY receptor genes found in extant vertebrates resulted from two genome duplications before the origin of jawed vertebrates (gnathostomes) and one additional genome duplication in the actinopterygian lineage, based on their location on chromosomes sharing several gene families. In this study we have investigated, in five vertebrate genomes, 45 gene families with members close to the NPY receptor genes in the compact genomes of the teleost fishes Tetraodon nigroviridis and Takifugu rubripes. These correspond to Homo sapiens chromosomes 4, 5, 8 and 10.

Results

Chromos

SUBMITTER: Larsson TA 

PROVIDER: S-EPMC2453138 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature