Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies.

ABSTRACT: The evolution of enzymes affects how well a species can adapt to new environmental conditions. During enzyme evolution, certain aspects of molecular function are conserved while other aspects can vary. Aspects of function that are more difficult to change or that need to be reused in multiple contexts are often conserved, while those that vary may indicate functions that are more easily changed or that are no longer required. In analogy to the study of conservation patterns in enzyme sequences and structures, we have examined the patterns of conservation and variation in enzyme function by analyzing graph isomorphisms among enzyme substrates of a large number of enzyme superfamilies. This systematic analysis of substrate substructures establishes the conservation patterns that typify indiv

SUBMITTER: Chiang RA 

PROVIDER: S-EPMC2453236 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature