Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury.

ABSTRACT:

Rationale

Mitochondria have important roles in intracellular energy generation, modulation of apoptosis, and redox-dependent intracellular signaling. Although reactive oxygen species (ROS) participate in the regulation of intracellular signaling pathways, including activation of nuclear factor (NF)-kappaB, there is only limited information concerning the role of mitochondrially derived ROS in modulating cellular activation and tissue injury associated with acute inflammatory processes.

Objectives

To examine involvement of the mitochondrial electron transport chain complex I on LPS-mediated NF-kappaB activation in neutrophils and neutrophil-dependent acute lung injury.

Methods

Neutrophils incubated with rotenone or metformin were treated with bacterial lipopolysacchari

SUBMITTER: Zmijewski JW 

PROVIDER: S-EPMC2453511 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature