Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.

ABSTRACT:

Background

The jumonji C (JmjC) domain containing gene 6 (Jmjd6, previously known as phosphatidylserine receptor) has misleadingly been annotated to encode a transmembrane receptor for the engulfment of apoptotic cells. Given the importance of JmjC domain containing proteins in controlling a wide range of diverse biological functions, we undertook a comparative genomic analysis to gain further insights in Jmjd6 gene organisation, evolution, and protein function.

Results

We describe here a semiautomated computational pipeline to identify and annotate JmjC domain containing proteins. Using a sequence segment N-terminal of the Jmjd6 JmjC domain as query for a reciprocal BLAST search, we identified homologous sequences in 62 species across all major phyla. Retrieved Jmjd6 sequen

SUBMITTER: Hahn P 

PROVIDER: S-EPMC2453528 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature