Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories.

ABSTRACT:

Background

The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors. Meta-analysis of microarray data from untreated or vehicle-treated animals within the control arm of toxicogenomics studies could yield useful information on baseline fluctuations in gene expression, although control animal data has not been available on a scale and in a form best served for data-mining.

Results

A dataset of control animal microarray expression data was assembled by a working group of the Health and Environmental Sciences Institute's Technical Committee on the Application of Genomics in Mechanism Based Risk Assessment in order to provide a public resource for

SUBMITTER: Boedigheimer MJ 

PROVIDER: S-EPMC2453529 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature