Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians.

ABSTRACT:

Objective

We performed a comprehensive genetic association study of common variation spanning the IGF2BP2 locus in order to replicate the association of the "confirmed" type 2 diabetes susceptibility variants rs4402960 and rs1470579 in the French Caucasian population and to further characterize the susceptibility variants at this novel locus.

Research design and methods

We genotyped a total of 21 tagging single nucleotide polymorphisms spanning the IGF2BP2 locus in our type 2 diabetes case-control cohort comprising 3,093 French Caucasian subjects.

Results

IGF2BP2 variants rs4402960 and rs1470579 were not associated with type 2 diabetes in the present study (P = 0.632 and P = 0.896, respectively). Meta-analysis of genotype data from over 34,000 subjects demonstrated th

SUBMITTER: Duesing K 

PROVIDER: S-EPMC2453612 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature