Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism.

ABSTRACT:

Objective

Adiponectin is an adipocyte-derived hormone that plays an important role in glucose and lipid metabolism. The main aims of this study are to investigate the effects of adiponectin on VLDL triglyceride (VLDL-TG) metabolism and the underlying mechanism.

Research design and methods

Adenoviruses were used to generate a mouse model with elevated circulating adiponectin. HepG2 and C2C12 cells were treated with recombinant human adiponectin.

Results

Three days after Ad-mACRP30 adenovirus injection, plasma adiponectin protein levels were increased 12-fold. All three main multimeric adiponectin molecules were proportionally elevated. Fasting plasma TG levels were significantly decreased (approximately 40%) in the mice with elevated adiponectin in circulation, as were

SUBMITTER: Qiao L 

PROVIDER: S-EPMC2453618 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature