Indel PDB: a database of structural insertions and deletions derived from sequence alignments of closely related proteins.

ABSTRACT:

Background

Insertions and deletions (indels) represent a common type of sequence variations, which are less studied and pose many important biological questions. Recent research has shown that the presence of sizable indels in protein sequences may be indicative of protein essentiality and their role in protein interaction networks. Examples of utilization of indels for structure-based drug design have also been recently demonstrated. Nonetheless many structural and functional characteristics of indels remain less researched or unknown.

Description

We have created a web-based resource, Indel PDB, representing a structural database of insertions/deletions identified from the sequence alignments of highly similar proteins found in the Protein Data Bank (PDB). Indel PDB utilize

SUBMITTER: Hsing M 

PROVIDER: S-EPMC2459192 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature