Integrated analysis of incidence, progression, regression and disappearance probabilities.

ABSTRACT:

Background

Age-related maculopathy (ARM) is a leading cause of vision loss in people aged 65 or older. ARM is distinctive in that it is a disease which can transition through incidence, progression, regression and disappearance. The purpose of this study is to develop methodologies for studying the relationship of risk factors with different transition probabilities.

Methods

Our framework for studying this relationship includes two different analytical approaches. In the first approach, one can define, model and estimate the relationship between each transition probability and risk factors separately. This approach is similar to constraining a population to a certain disease status at the baseline, and then analyzing the probability of the constrained population to develop a

SUBMITTER: Huang GH 

PROVIDER: S-EPMC2459200 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature