Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies.

ABSTRACT:

Background

Several studies have suggested that diabetes mellitus (DM) increases the risk of active tuberculosis (TB). The rising prevalence of DM in TB-endemic areas may adversely affect TB control. We conducted a systematic review and a meta-analysis of observational studies assessing the association of DM and TB in order to summarize the existing evidence and to assess methodological quality of the studies.

Methods and findings

We searched the PubMed and EMBASE databases to identify observational studies that had reported an age-adjusted quantitative estimate of the association between DM and active TB disease. The search yielded 13 observational studies (n = 1,786,212 participants) with 17,698 TB cases. Random effects meta-analysis of cohort studies showed that DM was ass

SUBMITTER: Jeon CY 

PROVIDER: S-EPMC2459204 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature