Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta.

ABSTRACT: The implantation of a foreign object in the brain produces an acute neuroinflammatory state in which glia (astrocytes and microglia) may remain chronically activated in response to the inert foreign object. Activated glia can exhibit a sensitized pro-inflammatory response to immunogenic stimuli. This may be relevant to intracranial cannula implantation, which is commonly used to administer substances directly into the brain. If intracranial cannulation activates glia, a subsequent neuroinflammatory stimulus might induce a potentiated pro-inflammatory response, thereby introducing a potential experimental confound. We tested the temporal and spatial responses of interleukin-1beta (IL-1beta) to an acute immune challenge produced by lipopolysaccharide (LPS) in animals with chronic bilateral i

SUBMITTER: Holguin A 

PROVIDER: S-EPMC2464278 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature