A simple and robust method for connecting small-molecule drugs using gene-expression signatures.

ABSTRACT:

Background

Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar pharmacological or toxicological properties by gene expression profile. Lamb et al first proposed the Connectivity Map [Lamb et al (2006), Science 313, 1929-1935] to make successful connections among small molecules, genes, and diseases using genomic signatures.

Results

Here we have built on the principles of the Connectivity Map to present a simpler and more robust method for the construction of reference gene-expression profiles and for the connection scoring scheme, which importantly allows the valuation of statisti

SUBMITTER: Zhang SD 

PROVIDER: S-EPMC2464610 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature