Remodeling of the Streptococcus agalactiae transcriptome in response to growth temperature.

ABSTRACT:

Background

To act as a commensal bacterium and a pathogen in humans and animals, Streptococcus agalactiae (group B streptococcus, GBS) must be able to monitor and adapt to different environmental conditions. Temperature variation is a one of the most commonly encountered variables.

Methodology/principal findings

To understand the extent to which GBS modify gene expression in response to temperatures encountered in the various hosts, we conducted a whole genome transcriptome analysis of organisms grown at 30 degrees C and 40 degrees C. We identified extensive transcriptome remodeling at various stages of growth, especially in the stationary phase (significant transcript changes occurred for 25% of the genes). A large proportion of genes involved in metabolism was up-regulated

SUBMITTER: Mereghetti L 

PROVIDER: S-EPMC2464734 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature