A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors.

ABSTRACT: Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately needed. One emerging strategy is to use the tumor tracking capacity inherent in many stem cell populations to deliver therapeutic agents to the brain cancer cells. Current limitations of the stem cell therapy strategy include that stem cells are treated as a single entity and lack of uniform technology is adopted for selection of clinically relevant sub-populations of stem cells. Specifically, therapeutic success relies on the selection of a clinically competent stem cell population based on their capacity of targeting brain tumors. A novel and generalizable organotypic slice platform to evaluat

SUBMITTER: Li SC 

PROVIDER: S-EPMC2474582 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature