The effects of protein interactions, gene essentiality and regulatory regions on expression variation.

ABSTRACT:

Background

Identifying factors affecting gene expression variation is a challenging problem in genetics. Previous studies have shown that the presence of TATA box, the number of cis-regulatory elements, gene essentiality, and protein interactions significantly affect gene expression variation. Nonetheless, the need to obtain a more complete understanding of such factors and how their interactions influence gene expression variation remains a challenge. The growth rates of yeast cells under several DNA-damaging conditions have been studied and a gene's toxicity degree is defined as the number of such conditions that the growth rate of the yeast deletion strain is significantly affected. Since toxicity degree reflects a gene's importance to cell survival under DNA-damaging conditions

SUBMITTER: Zhou L 

PROVIDER: S-EPMC2474594 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature