Evolution of SET-domain protein families in the unicellular and multicellular Ascomycota fungi.

ABSTRACT:

Background

The evolution of multicellularity is accompanied by the occurrence of differentiated tissues, of organismal developmental programs, and of mechanisms keeping the balance between proliferation and differentiation. Initially, the SET-domain proteins were associated exclusively with regulation of developmental genes in metazoa. However, finding of SET-domain genes in the unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe suggested that SET-domain proteins regulate a much broader variety of biological programs. Intuitively, it is expected that the numbers, types, and biochemical specificity of SET-domain proteins of multicellular versus unicellular forms would reflect the differences in their biology. However, comparisons across the unicellular and mul

SUBMITTER: Veerappan CS 

PROVIDER: S-EPMC2474616 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature