Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and child outcomes.

ABSTRACT:

Background

In observational studies, adequate selenium status has been associated with better pregnancy outcomes and slowed HIV disease progression.

Objective

We investigated the effects of daily selenium supplements on CD4 cell counts, viral load, pregnancy outcomes, and maternal and infant mortality among 913 HIV-infected pregnant women.

Design

In this randomized, double-blind, placebo-controlled trial, eligible women between 12 and 27 wk of gestation were given daily selenium (200 mug as selenomethionine) or placebo as supplements from recruitment until 6 mo after delivery. All women received prenatal iron, folic acid, and multivitamin supplements irrespective of experimental assignment.

Results

The selenium regimen had no significant effect on maternal CD4

SUBMITTER: Kupka R 

PROVIDER: S-EPMC2474659 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature