The total synthesis of (-)-cyanthiwigin F by means of double catalytic enantioselective alkylation.

ABSTRACT: Double catalytic enantioselective transformations are powerful synthetic methods that can facilitate the construction of stereochemically complex molecules in a single operation. In addition to generating two or more stereocentres in a single reaction, multiple asymmetric reactions also impart increased enantiomeric excess to the final product in comparison with the analogous single transformation. Furthermore, multiple asymmetric operations have the potential to independently construct several stereocentres at remote points within the same molecular scaffold, rather than relying on pre-existing chiral centres that are proximal to the reactive site. Despite the inherent benefits of multiple catalytic enantioselective reactions, their application to natural product total synthesis remains l

SUBMITTER: Enquist JA 

PROVIDER: S-EPMC2474750 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature