G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila.

ABSTRACT:

Background

The Drosophila circadian clock controls rhythms in the amplitude of odor-induced electrophysiological responses that peak during the middle of night. These rhythms are dependent on clocks in olfactory sensory neurons (OSNs), suggesting that odorant receptors (ORs) or OR-dependent processes are under clock control. Because responses to odors are initiated by heteromeric OR complexes that form odor-gated and cyclic-nucleotide-activated cation channels, we tested whether regulators of ORs were under circadian-clock control.

Results

The levels of G protein-coupled receptor kinase 2 (Gprk2) messenger RNA and protein cycle in a circadian-clock-dependent manner with a peak around the middle of the night in antennae. Gprk2 overexpression in OSNs from wild-type or cyc(01)

SUBMITTER: Tanoue S 

PROVIDER: S-EPMC2474769 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature