Characterization of intestinal inflammation and identification of related gene expression changes in mdr1a(-/-) mice.

ABSTRACT: Multidrug resistance targeted mutation (mdr1a (-/-) ) mice spontaneously develop intestinal inflammation. The aim of this study was to further characterize the intestinal inflammation in mdr1a (-/-) mice. Intestinal samples were collected to measure inflammation and gene expression changes over time. The first signs of inflammation occurred around 16 weeks of age and most mdr1a (-/-) mice developed inflammation between 16 and 27 weeks of age. The total histological injury score was the highest in the colon. The inflammatory lesions were transmural and discontinuous, revealing similarities to human inflammatory bowel diseases (IBD). Genes involved in inflammatory response pathways were up-regulated whereas genes involved in biotransformation and transport were down-regulated in colonic epit

SUBMITTER: Dommels YE 

PROVIDER: S-EPMC2474946 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature