Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

ABSTRACT:

Background

Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria.

Methodology/principal findings

We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficient media and hydrogen-peroxide-containing fermentable media. Out of a collection of approximately 2700 haploid yeast deletion mutants, 51 were sensitive to both conditions and 19 of these were related to mitochondrial function. Twelve deletion mutants lacked components of the electron transport chain. The growth defects of these mutants can be alleviated by the addition of antioxidants, w

SUBMITTER: Zuin A 

PROVIDER: S-EPMC2475502 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature