Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes.

ABSTRACT: The availability of 12 complete genomes of various species of genus Drosophila provides a unique opportunity to analyze genome-scale chromosomal rearrangements among a group of closely related species. This article reports on the comparison of gene order between these 12 species and on the fixed rearrangement events that disrupt gene order. Three major themes are addressed: the conservation of syntenic blocks across species, the disruption of syntenic blocks (via chromosomal inversion events) and its relationship to the phylogenetic distribution of these species, and the rate of rearrangement events over evolutionary time. Comparison of syntenic blocks across this large genomic data set confirms that genetic elements are largely (95%) localized to the same Muller element across genus Droso

SUBMITTER: Bhutkar A 

PROVIDER: S-EPMC2475759 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature