The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.

ABSTRACT: Chlorophyllin (CHL), an anticarcinogenic and antimutagenic water-soluble derivative of chlorophyll, has been reported to induce apoptosis in human colon cancer cells via a pathway involving cell differentiation. Induction of differentiation markers may be important in limiting cancer-cell invasion and metastasis, and there is much interest in understanding the underlying mechanisms, because this might provide insights for cancer chemotherapy. In the present study, human HCT116 colon-cancer cells were treated with CHL, and the expression levels of E-cadherin and beta-catenin were examined using immunocytochemistry and laser scanning confocal microscopy. E-cadherin was detected almost exclusively at the cell periphery of cancer cells treated with or without CHL, but the expression of E-cadhe

SUBMITTER: Carter O 

PROVIDER: S-EPMC2478518 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature