Development of gene expression signatures for practical radiation biodosimetry.

ABSTRACT:

Purpose

In a large-scale radiologic emergency, estimates of exposure doses and radiation injury would be required for individuals without physical dosimeters. Current methods are inadequate for the task, so we are developing gene expression profiles for radiation biodosimetry. This approach could provide both an estimate of physical radiation dose and an indication of the extent of individual injury or future risk.

Methods and materials

We used whole genome microarray expression profiling as a discovery platform to identify genes with the potential to predict radiation dose across an exposure range relevant for medical decision making in a radiologic emergency. Human peripheral blood from 10 healthy donors was irradiated ex vivo, and global gene expression was measured both

SUBMITTER: Paul S 

PROVIDER: S-EPMC2478639 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature