Protein profiling of the dimorphic, pathogenic fungus, Penicillium marneffei.

ABSTRACT:

Background

Penicillium marneffei is a pathogenic fungus that afflicts immunocompromised individuals having lived or traveled in Southeast Asia. This species is unique in that it is the only dimorphic member of the genus. Dimorphism results from a process, termed phase transition, which is regulated by temperature of incubation. At room temperature, the fungus grows filamentously (mould phase), but at body temperature (37 degrees C), a uninucleate yeast form develops that reproduces by fission. Formation of the yeast phase appears to be a requisite for pathogenicity. To date, no genes have been identified in P. marneffei that strictly induce mould-to-yeast phase conversion. In an effort to help identify potential gene products associated with morphogenesis, protein profiles were gen

SUBMITTER: Chandler JM 

PROVIDER: S-EPMC2478645 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature