High density linkage disequilibrium maps of chromosome 14 in Holstein and Angus cattle.

ABSTRACT:

Background

Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine chromosome 14 (BTA14) together with the bovine physical map have enabled the creation of more accurate LD maps for BTA14 in both dairy and beef cattle.

Results

Over 500 Single Nucleotide Polymorphism (SNP) markers from both Angus and Holstein animals had their phased haplotypes estimated using GENOPROB and their pairwise r2 values compared. For both breeds, results showed that average LD extends at moderate levels up to 100 kilo base pairs (kbp) and falls to background levels after 500

SUBMITTER: Marques E 

PROVIDER: S-EPMC2478670 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature