Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation.

ABSTRACT: Previously, we have identified a novel CCCH zinc finger protein family as negative regulators of macrophage activation. To gain an overall insight into the entire CCCH zinc finger gene family and to evaluate their potential role in macrophage activation, here we performed a genome-wide survey of CCCH zinc finger genes in mouse and human. Totally 58 CCCH zinc finger genes in mouse and 55 in human were identified and most of them have not been reported previously. Phylogenetic analysis revealed that the mouse CCCH family was divided into 6 groups. Meanwhile, we employed quantitative real-time PCR to profile their tissue expression patterns in adult mice. Clustering analysis showed that most of CCCH genes were broadly expressed in all of tissues examined with various levels. Interestingly, se

SUBMITTER: Liang J 

PROVIDER: S-EPMC2478707 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature