The endothelial glycocalyx is hydrodynamically relevant in arterioles throughout the cardiac cycle.

ABSTRACT: The existence of a hydrodynamically relevant endothelial glycocalyx of approximately 0.5 microm in thickness is well established in capillaries and venules in vivo. Since the glycocalyx is likely to have implications for broad areas of vascular physiology and pathophysiology, including endothelial-cell mechanotransduction, vascular permeability, and atherosclerosis, it is necessary to determine the extent to which the glycocalyx is present on arteriolar endothelium. We applied microviscometric analysis to data obtained using microparticle image velocimetry in cremaster-muscle arterioles of wild-type mice. Due to the pulsatile nature of the flow regimes in arterioles, data acquisition was triggered with the electrocardiogram at specific time points in the cardiac cycle. Results show the exi

SUBMITTER: Savery MD 

PROVIDER: S-EPMC2479580 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature