Proteomic profiling of hepatitis B virus-related hepatocellular carcinoma in China: a SELDI-TOF-MS study.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common malignancies with high mortality, but its underlying molecular mechanisms remain not well understood. High-throughput, proteomic techniques targeting unique biological molecules may provide novel insights into HCC pathogenesis and prognosis. In this study, we systemically investigated tissue biomarkers of HCC by using surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technique. Proteomic spectra were generated from fresh tissues (26 HCC and 18 control cirrhotic liver) and analyzed by using Biomarker Wizard System. A total of 16 differential proteomic peaks were detected between HCC and cirrhotic liver tissues, and 11 between moderately and highly differentiated HCCs. The expression patte

SUBMITTER: Zhang J 

PROVIDER: S-EPMC2480544 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature